| Title |
Journal |
Authors |
Year |
| The Influence of Autoimmune Thyroid Diseases on Viral Pneumonia Development, Including COVID-19: A Two-Sample Mendelian Randomization Study |
Pathogens |
Yi K, Tian M, Li X. |
2024 |
| Connecting atrial fibrillation to digestive neoplasms: exploring mediation via ischemic stroke and heart failure in Mendelian randomization studies |
Front Oncol |
Xu Z, Rao X, Xing Y, et al. |
2024 |
| Risk of Toxicity From Topical 5-Fluorouracil Treatment in Patients Carrying DPYD Variant Alleles |
Clin Pharmacol Ther |
Granados J, Pasternak AL, Henry NL, et al. |
2024 |
| Automated-detection of risky alcohol use prior to surgery using natural language processing |
Alcohol, Clinical and Experimental Research |
Vydiswaran VGV, Strayhorn A, Weber K, et al. |
2024 |
| Associations between metabolic hyperferritinaemia, fibrosis-promoting alleles and clinical outcomes in steatotic liver disease |
Liver International |
Suresh D, Li A, Miller MJ, et al. |
2024 |
| Risk scores for major bleeding from direct oral anticoagulants: comparing predictive performance in patients with atrial fibrillation |
Res Pract Thromb Haemost |
Campos-Staffico AM, Jacoby JP, Dorsch MP, et al. |
2024 |
| Multi-Ancestry Polygenic Risk Scores for Venous Thromboembolism. |
medRxiv |
Jee YH, Thibord F, Dominguez A, et al. |
2024 |
| Hemorrhoidal disease and its genetic association with depression, bipolar disorder, anxiety disorders, and schizophrenia: a bidirectional mendelian randomization study |
Human Genomics |
Huang Z, Huang J, Leung CK, et al. |
2024 |
| Clinical associations with a polygenic predisposition to benign lower white blood cell counts |
Nat Commun |
Mosley JD, Shelley JP, Dickson AL, et al. |
2024 |
| A framework for understanding selection bias in real-world healthcare data |
Statistics in Society |
Kundu R, Shi X, Morrison J, et al. |
2024 |
| Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction |
BMC Bioinformatics |
Zhuang Y, Kim NY, Fritsche LG, et al. |
2024 |
| Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence |
Cardiovasc Res |
Nielsen MB, Çolak Y, Benn M, et al. |
2024 |
| Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes |
JAMA Psychiatry |
Pathak GA, Singh K, Choi KW, et al. |
2024 |
| Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank |
Nat Genet |
Oliveri A, Rebernick RJ, Kuppa A, et al. |
2024 |
| To weight or not to weight? The effect of selection bias in 3 large electronic health record-linked biobanks and recommendations for practice |
J Am Med Inform Assoc |
Salvatore M, Kundu R, Shi X, et al. |
2024 |
| A genome-wide association study of susceptibility to upper urinary tract infections |
The Journal of Infectious Diseases |
Flatby HM, Ravi A, Liyanarachi KV, et al. |
2024 |
| Assessing the Clinical Utility of Published Prostate Cancer Polygenic Risk Scores in a Large Biobank Data Set |
Eur. Urol. Oncol. |
Vince RA, Sun H, Singhal U, et al. |
2024 |
| Mendelian randomization study of thyroid function and anti-Müllerian hormone levels |
Front Endocrinol |
Liang Z, Xu Z, Liu J. |
2023 |
| Polygenic prediction of preeclampsia and gestational hypertension. |
Nat Med |
Honigberg MC, Truong B, Khan RR, et al. |
2023 |
| Progression to cirrhosis is similar among all ages in nonalcoholic fatty liver disease, but liver-related events increase with age |
Hepatol Commun |
Miller MJ, Harding-Theobald E, DiBattista JV, et al. |
2023 |
| Proteome‐Wide Mendelian Randomization Analysis Identified Potential Drug Targets for Atrial Fibrillation |
Genome Medicine |
Al-Jumaan M, Chu H, Alsulaiman A, et al |
2023 |
| Major Genetic Risk Factors for Dupuytren’s Disease Are Inherited From Neandertals |
Molecular Biology and Evolution |
Ågren R, Patil S, Zhou X, et al. |
2023 |
| Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture |
Nat Commun |
Hao X, Shao Z, Zhang N, et al. |
2023 |
| Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries |
Cell Genomics |
Surakka I, Wu K-H, Hornsby W, et al. |
2023 |
| Genetic associations of persistent opioid use after surgery: a hypothesis-driven analysis of high-value genetic variants in the Michigan Genomics Initiative dataset |
Research Square preprint |
Brummett C, Annis A, Gunaseelan V, et al. |
2023 |
| Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of Both IBD and Adverse Bone Health Outcomes Highlighting Common Genetic Underpinnings Across Both Diseases |
Inflamm Bowel Dis |
Cushing KC, Chen Y, Du X, et al. |
2023 |
| Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data |
Epidemiol Health |
Salvatore M, Clark-Boucher D, Fritsche LG, et al. |
2023 |
| A pilot genome-wide association study meta-analysis of gastroparesis |
United European Gastroenterology Journal |
Tavares LC, Zheng T, Kwicklis M, et al. |
2023 |
| PNPLA3 Risk Allele Association With ALT Response to Semaglutide Treatment |
Gastroenterology |
Urias E, Tedesco NR, Oliveri A, et al. |
2023 |
| Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks |
PLoS Genet |
Fritsche LG, Nam K, Du J, et al. |
2023 |
| Predicting persistent opioid use after hand surgery: a machine learning approach |
Plast Reconstr Surg |
Baxter NB, Ho AZ, Byrd JN, et al. |
2023 |
| Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease |
Nat Genet |
Chen Y, Du X, Kuppa A, et al. |
2023 |
| Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus |
Nat Commun |
Khunsriraksakul C, Li Q, Markus H, et al. |
2023 |
| Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes |
Genetic Epidemiology |
Shoaib M, Ye Q, IglayReger H, et al. |
2023 |
| PNPLA3 Genotype and Diabetes Identify Patients With Nonalcoholic Fatty Liver Disease at High Risk of Incident Cirrhosis |
Gastroenterology |
Chen VL, Oliveri A, Miller MJ, et al. |
2023 |
| Identifying the prevalence of clinically actionable drug-gene interactions in a health system biorepository to guide pharmacogenetics implementation services |
Clinical and Translational Science |
Pasternak AL, Ward K, Irwin M, et al. |
2023 |
| Meta-analysis fine-mapping is often miscalibrated at single-variant resolution |
Cell Genomics |
Kanai M, Elzur R, Zhou W, et al. |
2022 |
| Eight pharmacokinetic genetic variants are not associated with the risk of bleeding from direct oral anticoagulants in non-valvular atrial fibrillation patients |
Frontiers in Pharmacology |
Campos-Staffico AM, Dorsch MP, Barnes GD, et al. |
2022 |
| Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis |
Genome Biology |
Kanoni S, Graham SE, Wang Y, et al. |
2022 |
| Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
Commun Biol |
Winkler TW, Rasheed H, Teumer A, et al. |
2022 |
| COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study |
Thyroid |
Li GH-Y, Tang C-M, Cheung C-L. |
2022 |
| Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity |
Cell Genom |
Tsuo K, Zhou W, Wang Y, et al. |
2022 |
| The Phenotype-Genotype Reference Map: Improving biobank data science through replication |
bioRxiv |
Bastarache L, Delozier S, Pandit A, et al. |
2022 |
| The Michigan Genomics Initiative: A biobank linking genotypes and electronic clinical records in Michigan Medicine patients |
Cell Genomics |
Zawistowski M, Fritsche LG, Pandit A, et al. |
2022 |
| Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics |
Cell Genomics |
Partanen JJ, Häppölä P, Zhou W, et al. |
2022 |
| Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease |
Cell Genomics |
Zhou W, Kanai M, Wu K-HH, et al. |
2022 |
| ExPRSweb: An online repository with polygenic risk scores for common health-related exposures |
Am J Hum Genet |
Ma Y, Patil S, Zhou X, et al. |
2022 |
| Genetic variants associated with sepsis |
PLoS One |
Engoren M, Jewell ES, Douville N, et al. |
2022 |
| Impact of Pharmacogenetics on Intravenous Tacrolimus Exposure and Conversions to Oral Therapy |
Transplant Cell Ther |
Pasternak AL, Marcath LA, Li Y, et al. |
2022 |
| A Substitution in the Glutathione Reductase Lowers Electron Leakage and Inflammation in Modern Humans |
Science Advances |
Coppo L, Mishra P, Siefert N, et al. |
2022 |
| The Major Genetic Risk Factor for Severe COVID-19 Is Associated with Protection against HIV |
Proc Natl Acad Sci USA |
Zeberg H. |
2022 |
| Predicting Persistent Opioid Use after Surgery Using Electronic Health Record and Patient-Reported Data |
Surgery |
Singh K, Murali A, Stevens H, et al. |
2022 |
| A first update on mapping the human genetic architecture of COVID-19 |
Nature |
Pathak GA, Karjalainen J, Stevens C, et al. |
2022 |
| Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-Wide Association Study of 46,782 Individuals |
Biol Psychiatry |
Fang Y, Fritsche LG, Mukherjee B, et al. |
2022 |
| Assessing the Added Value of Linking Electronic Health Records to Improve the Prediction of Self-Reported COVID-19 Testing and Diagnosis |
PLoS One |
Clark-Boucher D, Boss J, Salvatore M, et al. |
2022 |
| Polygenic Risk Prediction in Diverticulitis |
Ann Surg |
De Roo AC, Chen Y, Du X, et al. |
2022 |
| Genome-Wide Meta-Analysis of Iron Status Biomarkers and the Effect of Iron on All-Cause Mortality in HUNT |
Commun Biol |
Moksnes MR, Graham SE, Wu K-H, et al. |
2022 |
| Hepatic decompensation is accelerated in patients with cirrhosis and alpha-1 antitrypsin Pi∗MZ genotype |
JHEP Rep |
Chen VL, Burkholder DA, Moran IJ, et al |
2022 |
| Inflammatory Bowel Disease Risk Variants Are Associated with an Increased Risk of Skin Cancer |
Inflamm Bowel Dis |
Cushing KC, Du X, Chen Y, et al. |
2022 |
| The Construction of Multi-Ethnic Polygenic Risk Score Using Transfer Learning |
medRxiv |
Zhao Z, Fritsche LG, Smith JA, et al. |
2022 |
| Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization Study |
The Journal of Clinical Endocrinology & Metabolism |
Larsson SC, Lee W-H, Burgess S, et al. |
2021 |
| The Power of Genetic Diversity in Genome-Wide Association Studies of Lipids |
Nature |
Graham SE, Clarke SL, Wu K-HH, et al. |
2021 |
| On Cross-Ancestry Cancer Polygenic Risk Scores |
PLoS Genet |
Fritsche LG, Ma Y, Zhang D, et al. |
2021 |
| False Discovery Rates for Genome-Wide Association Tests in Biobanks with Thousands of Phenotypes |
Research Square preprint |
Annis A, Pandit A, LeFaive J, et al. |
2021 |
| Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents |
PLoS One |
Wu K-HH, Hornsby WE, Klunder B, et al. |
2021 |
| A powerful subset-based method identifies gene set associations and improves interpretation in UK Biobank |
Am J Hum Genet |
Dutta D, VandeHaar P, Fritsche LG, et al. |
2021 |
| A survey of functional dyspepsia in 361,360 individuals: Phenotypic and genetic cross‐disease analyses |
Neurogastroenterology & Motility |
Garcia-Etxebarria K, Carbone F, Teder-Laving M, et al. |
2021 |
| Genetic association studies of fibromuscular dysplasia identify new risk loci and shared genetic basis with more common vascular diseases |
Nat Commun |
Georges A, Yang M-L, Berrandou T-E, et al. |
2021 |
| Mapping the human genetic architecture of COVID-19 |
Nature |
Niemi MEK, Karjalainen J, Liao RG, et al. |
2021 |
| Disclosure of clinically actionable genetic variants to thoracic aortic dissection biobank participants |
BMC Med Genomics |
Beil A, Hornsby W, Uhlmann WR, et al. |
2021 |
| Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease |
Gut |
Zheng T, Ellinghaus D, Juzenas S, et al. |
2021 |
| Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm |
Am J Hum Genet |
Roychowdhury T, Lu H, Hornsby WE, et al. |
2021 |
| Genome-Wide Association Study of Pelvic Organ Prolapse Using the Michigan Genomics Initiative |
Female Pelvic Med Reconstr Surg |
Cox CK, Pandit A, Zawistowski M, et al. |
2021 |
| Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction |
Human Molecular Genetics |
Palmer ND, Kahali B, Kuppa A, et al. |
2021 |
| Patients carrying DPYD variant alleles have increased risk of severe toxicity and related treatment modifications during fluoropyrimidine chemotherapy |
Pharmacogenomics |
Shakeel F, Fang F, Kwon JW, et al. |
2021 |
| Why are rare variants hard to impute? Coalescent models reveal theoretical limits in existing algorithms |
Genetics |
Si Y, Vanderwerff B, Zöllner S |
2021 |
| Phenotype risk scores (PheRS) for pancreatic cancer using time-stamped electronic health record data: Discovery and validation in two large biobanks |
J Biomed Inform |
Salvatore M, Beesley LJ, Fritsche LG, et al. |
2021 |
| Genetic mutations associated with susceptibility to perioperative complications in a longitudinal biorepository with integrated genomic and electronic health records |
Br J Anaesth |
Douville NJ, Kheterpal S, Engoren M, et al. |
2020 |
| Use of a Polygenic Risk Score Improves Prediction of Myocardial Injury After Non-Cardiac Surgery |
Circ Genom Precis Med |
Douville NJ, Surakka I, Leis A, et al. |
2020 |
| GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer |
Nat Commun |
Zhou W, Brumpton B, Kabil O, et al. |
2020 |
| Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease |
Nat Commun |
Nielsen JB, Rom O, Surakka I, et al. |
2020 |
| Chromosome 1q21. 2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction |
Nat Commun |
Saw J, Yang M-L, Trinder M, et al. |
2020 |
| LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanks |
PLoS Genet |
Goldstein JA, Weinstock JS, Bastarache LA, et al. |
2020 |
| Statistical inference for association studies using electronic health records: handling both selection bias and outcome misclassification |
Biometrics |
Beesley LJ, Mukherjee B |
2020 |
| Novel score test to increase power in association test by integrating external controls |
Genet Epidemiol |
Li Y, Lee S |
2020 |
| Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks |
Am J Hum Genet |
Fritsche LG, Patil S, Beesley LJ, et al. |
2020 |
| An analytic framework for exploring sampling and observation process biases in genome and phenome-wide association studies using electronic health records |
Stat Med |
Beesley LJ, Fritsche LG, Mukherjee B |
2020 |
| Interaction analysis under misspecification of main effects: Some common mistakes and simple solutions |
Stat Med |
Zhang M, Yu Y, Wang S, et al. |
2020 |
| The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential opportunities |
Stat Med |
Beesley LJ, Salvatore M, Fritsche LG, et al. |
2020 |
| Genetic variants that associate with cirrhosis have pleiotropic effects on human traits |
Liver Int |
Chen VL, Chen Y, Du X, et al. |
2020 |
| Heritability of the Fibromyalgia Phenotype Varies by Age |
Arthritis Rheumatol |
Dutta D, Brummett CM, Moser SE, et al. |
2020 |
| Estimation of DNA contamination and its sources in genotyped samples |
Genet Epidemiol |
Zajac GJM, Fritsche LG, Weinstock JS, et al. |
2019 |
| Meta-MultiSKAT: Multiple phenotype meta-analysis for region-based association test |
Genet Epidemiol |
Dutta D, Gagliano Taliun SA, Weinstock JS, et al. |
2019 |
| Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis |
Hepatol Commun |
Chen VL, Wright AP, Halligan B, et al. |
2019 |
| Health Care Burden Associated with Outpatient Opioid Use Following Inpatient or Outpatient Surgery |
J Manag Care Spec Pharm |
Brummett CM, England C, Evans-Shields J, et al. |
2019 |
| Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWeb |
PLoS Genet |
Fritsche LG, Beesley LJ, VandeHaar P, et al. |
2019 |
| Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis |
Nat Commun |
Graham SE, Nielsen JB, Zawistowski M, et al. |
2019 |
| Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes |
Nat Commun |
Gusarova V, O’Dushlaine C, Teslovich TM, et al. |
2018 |
| Biobank-driven genomic discovery yields new insight into atrial fibrillation biology |
Nat Genet |
Nielsen JB, Thorolfsdottir RB, Fritsche LG, et al. |
2018 |
| Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease |
Nat Genet |
Maguire LH, Handelman SK, Du X, et al. |
2018 |
| Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative |
Am J Hum Genet. |
Fritsche LG, Gruber SB, Wu Z, et al. |
2018 |
| Association of Rare Predicted Loss-of-Function Variants in Cellular Pathways with Sub-Phenotypes in Age-Related Macular Degeneration |
Ophthalmology |
Pietraszkiewicz A, van Asten F, Kwong A, et al. |
2018 |
| Prevalence of Preoperative Opioid Use and Characteristics Associated With Opioid Use Among Patients Presenting for Surgery |
JAMA Surgery |
Hilliard PE, Waljee J, Moser S, et al. |
2018 |
| Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development |
Am J Hum Genet |
Nielsen JB, Fritsche LG, Zhou W, et al. |
2018 |
| Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve |
Nat Commun |
Yang B, Zhou W, Jiao J, et al. |
2017 |
| A Fast and Accurate Algorithm to Test for Binary Phenotypes and Its Application to PheWAS |
Am J Hum Genet |
Dey R, Schmidt EM, Abecasis GR, et al. |
2017 |
