Workgroups

Cohort Development

Cohort Development includes the creation, curation, and exposure of novel datasets enabling precision health research throughout campus, as well as the recruitment, engagement, and retention of a large, diverse community of consented participants.

Workgroup Leaders:

Bhramar Mukherjee, PhD
Associate Workgroup Director

Bhramar Mukherjee is a Professor in the Department of Biostatistics and in the Department of Epidemiology. She completed her PhD in 2001 from Purdue University. Dr. Mukherjee’s principal research interests lie in Bayesian methods in epidemiology and studies of gene-environment interaction. Her collaborative interests focus on genetic and environmental epidemiology, ranging from investigating the genetic architecture of colorectal cancer in relation to environmental exposures to studies of air pollution on pediatric asthma events in Detroit. She is actively engaged in Global Health Research.

Lynda Lisabeth, PhD, MPH
Assistant Workgroup Director

Lynda Lisabeth is Professor of Epidemiology in the School of Public Health at the University of Michigan and Research Professor of Neurology at the University of Michigan Medical School. Dr. Lisabeth studies the epidemiology of stroke in the United States, with a focus on stroke health disparities in the Mexican American population. Dr. Lisabeth received her PhD in Epidemiologic Science and MPH in Biostatistics from the University of Michigan. She has been involved in strategic planning efforts for the National Institute for Neurologic Disorders and Stroke surrounding the advancement of stroke research and the elimination of stroke disparities.

Cristen Willer, PhD
Assistant Workgroup Director

Cristen Willer is an Assistant Professor in Internal Medicine (Cardiology), with joint appointments in the Department of Human Genetics and the Department of Computational Medicine and Bioinformatics. Willer’s research aims to characterize the genetic basis of cardiovascular disease and related traits in human populations. She studied for a B.Sc. in Molecular Biology and Biochemistry at McMaster University and a PhD at Oxford University at the Wellcome Trust Center for Human Genetics, and followed that with a statistical genetics postdoctoral fellowship at U-M’s Department of Biostatistics. Willer has published peer-reviewed in journals such as Nature, Science, Nature Genetics, JAMA, PNAS, New England Journal of Medicine, Lancet, and BMJ.

 

Workgroup Goals:

  • Develop and expose a novel integrated dataset
    • Integrate data spanning various clinical, administrative, and mobile sources, obviating the need for individual researchers to perform data integration
    • Transparently curate and clean data to allow researchers access to re-usable datasets
    • Incorporate techniques to minimize privacy risks while maximizing re-use of data
    • Identify and overcome internal and external regulatory burdens to data access
    • Integrate publicly available datasets regarding environmental exposure, socioeconomic status, and disparities
  • Transform the Michigan Genomics Initiative recruiting process into a modern, scalable participant community for precision health research across campus
    • Continue to recruit, consent, and retain 10,000 participants per year through the Michigan Medicine perioperative process
    • Expand to include patients recruited through outpatient clinics
    • Expand to include pediatric patients recruited through the perioperative process
    • Enrich the dataset with novel datastreams including wearables, new sensors, and focused sub-groups
    • Transform specimen collection, processing, and analysis into a CLIA-compliant system that enables novel analytics
    • Increase outreach, participant engagement, and follow-up communication