The Michigan Genomics Initiative (MGI) is a valuable resource available to all University of Michigan researchers, currently providing comprehensive genetic data for > 80K participants. These data can be connected to MiChart for retrospective genetic analyses without the need to enroll study participants, collect specimens, or genotype samples.

One of the major use cases for MGI is pharmacogenomics (PGx) studies that investigate the genetic predictors of medication treatment outcomes. These studies typically require the translation of genetic data into functionally relevant haplotypes, also known as star (*) alleles, and predicted activity phenotypes.

To enhance the usefulness of MGI data for conducting PGx studies, we provide in-silico inferences for star alleles and activity phenotypes for 15 important pharmacogenes. New with this release are inferences for carrier status of the important loss-of-function whole gene deletion CYP2D6 *5 allele, which we infer based on genotype array intensities.

To access these pharmacogenetic data, please submit a “Custom Data Request” in JIRA. Users will receive each participant’s inferred star alleles and activity phenotype in an accessible, analysis-ready format. To learn more about this free PGx service, please contact phdatahelp@umich.edu.