Precision Health’s Michigan Genomics Initiative is pleased to announce the completion of the genotype calling, quality control, and imputation for Freeze 6 of the MGI genotype dataset. Changes from Freeze 5 include:

• Available genotyped cohort size increased by 10,306 participants.
• Phasing of all MGI samples performed with TOPMed as reference. In Freeze 5, samples assayed on the CoreExome array were phased without a reference panel.\

The new dataset is just over 80K individuals with ≈ 20K individuals assayed on our new Global Screening Array and ≈ 60K individuals assayed on our legacy CoreExome arrays. The inferred majority genetic ancestry of the participants included as a part of Freeze 6 is primarily European (n=69,589) with smaller numbers of African (n=4,993), Western Asian (n=2,260), Eastern Asian (n=1,784), Central/South Asian (n=1,181), and Native American (n=722). This release has been imputed with the Trans-Omics for Precision Medicine (TOPMed) panel as reference. See the readme for more information and technical details.

To access these data, please apply through our ticketing system (submit a ”Custom Data Request” in JIRA): https://doctrjira.med.umich.edu/. You will need to submit an IRB application through IRBMED to access these data, which you can apply for in eResearch Regulatory Management: https://its.umich.edu/academics-research/research/eresearch. For further assistance, please contact the Research Scientific Facilitators at phdatahelp@umich.edu, who can guide you through the data request process.