Use Case: Precision Opioid Prescribing

Precision Health at the University of Michigan will support a variety of precision-related research projects — across a broad spectrum of disciplines — occurring at U-M. Our focus on opioid prescribing in the pre-surgical setting presents a use case that will allow us to test and refine the resources and infrastructure that will be most useful to researchers—knowledge that we will apply to the additional projects Precision Health will undertake in 2018.

Opioid misuse is a serious public health crisis that’s been sweeping across the United States. Currently, 78 Americans die each day due to opioid-related overdoses. The vast majority of individuals who become dependent on prescription opioids receive their first dose following surgical care. Precision Health at the University of Michigan is focusing on understanding the factors that put people at risk of long-term opioid use so that these patients can be prescribed alternative pain management strategies when having surgery.

An important resource Precision Health will draw on for this use case is the Michigan Opioid Prescribing Engagement Network (Michigan-OPEN). Led by U-M researchers, Michigan OPEN aims to ensure appropriate acute pain care following surgery, while protecting patients and communities by raising awareness about opioid misuse and creating interventions that reduce postoperative opioid prescribing and patient consumption.

The Michigan Genomics Initiative (MGI) is another valuable data resource that will inform Precision Health’s work on precision opioid prescribing. Containing health information from 50,000 subjects, MGI is an institutional repository of DNA and genetic and phenotypic data for future medical research. MGI is committed to advancing the understanding of health, wellness, and the development of disease; to predicting response to treatments; and to advancing drug development.